A new study by Nicolas Hulscher and a team of researchers, published on July 25, 2025, on Preprints.org, has raised further serious concerns about the safety of COVID-19 mRNA vaccines. Titled "Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination," it suggests that these vaccines might cause long-lasting changes in how our genes work, potentially leading to serious health problems like cancer and chronic diseases. For those of us who aren't scientists, let's break this down into plain English to understand what the study says, why it matters, and what questions it leaves unanswered.

What Did the Study Do?

The researchers looked at blood samples from two groups of people who had issues after getting mRNA vaccines (like Pfizer or Moderna):

Three people with new health problems, like neurological issues, heart problems, or chronic fatigue.

Seven people diagnosed with cancer after vaccination. They compared these folks to 803 healthy people who hadn't shown these problems. Using advanced tools like RNA sequencing (a way to read what genes are doing), they checked for changes in gene activity. Think of genes as instructions your body follows to stay healthy, when those instructions get scrambled, things can go wrong.

What Did They Find?

The study claims that mRNA vaccines mess with thousands of genes in ways that could cause trouble. Here's what they say is happening:

Mitochondrial Problems: Mitochondria are like your cells' power plants. The study found that the vaccines disrupt them, causing energy shortages and stress in cells, which could lead to fatigue or brain issues.

Immune System Overdrive: The vaccines seem to keep the immune system in a constant "fight mode," causing inflammation that doesn't go away. This could lead to chronic illnesses or even help cancers hide from the immune system.

Cancer Signals: The study saw signs that the vaccines turn on genes linked to cancer (like MYC) and turn off genes that fight tumours (like p53 and KRAS). This could make it easier for cancers to start or grow.

Protein and Cell Stress: The vaccines' synthetic mRNA, which uses a modified ingredient called N1-methylpseudouridine, seems to overwhelm the body's protein-making machinery, leading to errors and stress in cells.

Blood Clot and Heart Risks: Genes that control blood vessels and clotting were less active, which might explain why some people have had blood clots or heart issues after vaccination.

Possible DNA Changes: The study hints that the vaccine's mRNA might get "reverse transcribed" into DNA, meaning it could stick around in your body longer than expected, potentially causing ongoing problems. They also mention leftover plasmid DNA (from the vaccine manufacturing process) as a possible issue.

These effects, the researchers say, could last months or even years, raising the risk of cancer, immune disorders, or other chronic conditions.

Why This Sounds Scary

The idea that a vaccine could mess with your genes long-term is alarming, especially when we were told these shots were safe and temporary. The study suggests that the spike protein (the part of the virus the vaccine tells your body to make) sticks around, causing chaos in your cells. It also points to cancer risks, which is a big deal; nobody wants to hear that something they took to stay healthy might increase their chances of getting sick in a different way. The researchers are so concerned that they're calling for mRNA vaccines to be pulled from use, arguing that the risks outweigh the benefits for the roughly 20% of people still considering boosters.

If you've had an mRNA vaccine, don't lose sleep just yet. This study raises red flags, but it's not the final word. Here's what you can take away:

Stay Informed: Keep an eye on follow-up studies. If bigger, peer-reviewed research confirms these findings, it could change how we view mRNA vaccines.

Talk to Your Doctor: If you're worried about vaccine side effects or booster shots, discuss your health history with a trusted healthcare provider. They can help weigh risks and benefits.

Healthy Habits Matter: Whether or not the vaccine concerns are true, focusing on exercise, good nutrition, and stress management can boost your overall health and resilience.

Scepticism is Healthy, But So is Balance: The study's authors have a history of strong anti-vaccine views, which doesn't mean they're wrong.

The Hulscher study is a provocative warning about potential long-term risks of mRNA vaccines, suggesting they could disrupt genes in ways that lead to cancer or chronic disease. It's a serious claim, but the small sample size and lack of peer review mean we need more data to know if it's true. If it is true, this is a major blow to the "safe and effective" ideology, or mythology.

https://www.thefocalpoints.com/p/breaking-study-mrna-injections-induce

BREAKING STUDY: mRNA Injections Induce Severe, Long-Lasting Genetic Disruption Linked to Cancer and Chronic Disease Landmark study reveals COVID-19 "vaccines" severely disrupt the expression of thousands of genes—triggering mitochondrial failure, immune reprogramming, and oncogenic activation.

By Nicolas Hulscher, MPH

In a ground-breaking landmark study titled "Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination"—just uploaded to Preprints.org—we discovered that COVID-19 mRNA injections can trigger profound, long-lasting genetic dysregulation in individuals who develop new-onset adverse events or cancer following vaccination.

The study was conducted by scientists from Neo7Bioscience (Dr. John Catanzaro, Dr. Natalia von Ranke, Dr. Wei Zhang, Dr. Philipp Anokin), the University of North Texas (Dr. Danyang Shao, Dr. Ahmad Bereimipour, Minh Vu), the McCullough Foundation (Dr. Peter McCullough and Nicolas Hulscher) and Medicinal Genomics (Kevin McKernan).

Using high-resolution RNA sequencing of blood samples and differential gene expression analysis, we found that COVID-19 "vaccines" severely disrupted the expression of thousands of genes—inducing mitochondrial failure, immune system reprogramming, and oncogenic activation that persisted for months to years after injection.

METHODS

The study analyzed whole blood RNA profiles from:

3 patients with new-onset adverse events (neurological, cardiovascular, chronic fatigue) following mRNA vaccination

7 patients newly diagnosed with cancer post-mRNA vaccination

803 healthy controls

Key tools and analyses:

Bulk RNA sequencing (Illumina NextSeq) of patient blood samples

DESeq2 for differential gene expression analysis

Gene Set Enrichment Analysis (GSEA) to identify disrupted biological pathways

STRING + Cytoscape to visualize protein-protein interaction (PPI) networks of dysregulated genes

FINDINGS mRNA Vaccines Trigger Transcriptomic Chaos

Both vaccine injured groups showed massive gene dysregulation compared to healthy controls—hundreds of genes up- or down-regulated, especially in pathways tied to:

Mitochondrial dysfunction

Protein folding and degradation stress (proteasome pathways)

Ribosomal overload and nonsense-mediated decay (NMD)

Chronic systemic inflammation

Oncogenic activation (MYC) and tumor suppressor suppression (p53, KRAS)

Shared Hallmarks in Both Groups

Mitochondrial Dysfunction & Oxidative Stress
Complex I disruptions and ROS overproduction—core features of chronic fatigue and neurodegeneration.

Ribosomal Stress & Translational Overdrive
Synthetic mRNA with modified bases (N1-methylpseudouridine) appears to trigger ribosomal overload, translation errors, and RNA surveillance activation. These stress signatures are also consistent with host responses to foreign genetic material, and may reflect reverse transcription of mRNA via endogenous LINE-1 activity, residual plasmid DNA, or vector-derived promoter activity—raising the possibility of persistent transcription or genomic integration.

Proteasome Activation
Likely due to spike protein persistence and accumulation of misfolded proteins.

Endothelial Dysfunction & Coagulopathy
Genes regulating angiogenesis and coagulation were downregulated—mirroring thrombotic complications post-vaccination.

Oncogenic Signals
Activation of MYC, suppression of p53 and KRAS inhibitors, setting the stage for tumor growth.

Cancer Group Shows Additional Red Flags

Genomic Instability & Epigenetic Reprogramming
Strong upregulation of genes linked to chromatin remodeling, DNA methylation, and nucleosome displacement—hallmarks of early tumorigenesis.

Hyperactivation of Type I Interferon and Toll-like Receptor (TLR) Pathways
Persistent immune system stimulation via TLRs, IRFs, and JAK-STAT—common in both chronic inflammation and cancer immune escape.

ACE2 Downregulation
Both groups showed severe suppression of ACE2, activating the Ang II → AT1R → NF-κB/MAPK cascade—a known tumor-promoting and inflammatory loop.

To our knowledge, this is the first study to show long-term genetic disruption in individuals harmed by the COVID-19 mRNA injections.

These findings strongly suggest:

mRNA vaccines can induce gene expression profiles consistent with tumor formation and chronic disease

mRNA-vaccinated individuals may be at heightened risk of cancer, immune dysfunction, and inflammatory disorders

The synthetic mRNA and long-lasting spike protein appear to create sustained cellular stress that disrupts normal genetic regulation

Signatures suggest potential reverse transcription of vaccine mRNA and persistence of plasmid DNA—raising concern for long-term transcriptional interference or possible genomic integration

It's time for the immediate withdrawal of these dangerous gene therapies to protect the remaining ~20% of the population still considering booster doses.

von Ranke N, Zhang W, Anokin P, Shao D, Bereimipour A, Vu M, Hulscher N, McKernan KJ, McCullough PA, Catanzaro JA. Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence From New-Onset Adverse Events and Cancers Post-Vaccination. Preprints. 2025;2025072155. doi:10.20944/preprints202507.2155.v1